IHC and CISH stains
Diagnosis: Polymorphic post-transplant lymphoproliferative disorder (PTLD)
Polymorphic lymphoproliferative disorder arising in immune deficiency (post transplant) (WHO 5th)
Essential diagnostic criteria
Setting confirmed or highly suspicious for immune deficiency/dysregulation
Architectural effacement
Polymorphous infiltrate with a spectrum of stages B-cell differentiation
Atypical large cells positive for CD20 (variable), CD30 (variable), and PAX5
EBV+ demonstrated in tissue (EBV viral load measurements in the blood are not sufficient for diagnosis)
Polymorphic lymphoproliferative disorder arising in immune deficiency (post transplant) (WHO 5th)
Essential diagnostic criteria
Setting confirmed or highly suspicious for immune deficiency/dysregulation
Architectural effacement
Polymorphous infiltrate with a spectrum of stages B-cell differentiation
Atypical large cells positive for CD20 (variable), CD30 (variable), and PAX5
EBV+ demonstrated in tissue (EBV viral load measurements in the blood are not sufficient for diagnosis)