Flow cytometry study:
FISH: PML-RARA fusion is detected in most of the cells.
Red = PML locus (15q22)
Green = RARA locus (17q21)
Red/Green = PML/RARA fusion (overlap = yellow)
Red = PML locus (15q22)
Green = RARA locus (17q21)
Red/Green = PML/RARA fusion (overlap = yellow)
Diagnosis:
Acute Promyelocytic Leukemia with t(15;17)(q22; q21)PML-RARA, classical type (FAB, M3).
Treated with ATRA and Arsenic.
End of induction (Day29) PB and BM show rare Auer rods in mature neutrophils.
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