Hyaline Vascular Castleman Disease:
•Young adults
•Common location: mediastinum or neck
•Microscopic:
–Concentric layering of lymphocytes
–Atrophic germinal center (GC), multiple GCs
–Small hyaline vessels radially penetrating the GC (lollipop)
–Vascular interfollicular tissue
•Reactive process, curable by surgical resection
•Monoclonality shown in recent study
–Chang KC, et al. Modern Path (2014) 27, 823-831
•Young adults
•Common location: mediastinum or neck
•Microscopic:
–Concentric layering of lymphocytes
–Atrophic germinal center (GC), multiple GCs
–Small hyaline vessels radially penetrating the GC (lollipop)
–Vascular interfollicular tissue
•Reactive process, curable by surgical resection
•Monoclonality shown in recent study
–Chang KC, et al. Modern Path (2014) 27, 823-831