IHC stains
Kikuchi Disease:
•Young female, asian
•Fever and painful cervical LN
•Widespread apoptosis and necrosis, karyorrhectic debris, no neutrophils
•Paracortical Small Lymphocytes (CD8+>CD4+>>B cell), immunoblasts, plasmacytoid dendritic cells (CD123+), histocytes (MPO+), and plasma cells
•Phagocytic histiocytes---crescentic nuclei
Benign course, spontaneous remission in 1-4months
DDx:
-SLE
-Early stage: large cell lymphoma
•Young female, asian
•Fever and painful cervical LN
•Widespread apoptosis and necrosis, karyorrhectic debris, no neutrophils
•Paracortical Small Lymphocytes (CD8+>CD4+>>B cell), immunoblasts, plasmacytoid dendritic cells (CD123+), histocytes (MPO+), and plasma cells
•Phagocytic histiocytes---crescentic nuclei
Benign course, spontaneous remission in 1-4months
DDx:
-SLE
-Early stage: large cell lymphoma