13 months old boy comes for abnormal newborn screening test for hemoglobinapathy. CBC: WBC, 11.78K/uL (6.00 - 17.50); HGB, 10.4 gm/dL (10.5 - 13.5), HCT, 29.7 % (33.0 - 39.0); platelet, 445 K/uL (150 – 450); RBC, 5.48 M/uL(3.70 - 5.30 ), MCV , 54.2 fL (70.0 - 86.0 ), MCH, 19.0 pg (23.0 - 30.0), MCHC, 35.0 gm/dL (31.5 - 36.5), RDW, 19.3% (11.5 - 14.5).
Capillary electrophoresis:
HPLC study:
Diagnosis: HbE/beta thalassemia