IHC stains:
Diagnosis: Primary cutaneous CD30-positive T-cell lymphoproliferative disorder (CD30+PCLPD)
CD30+PCLPDs are the second most common group of the cutaneous T-cell lymphomas (CTCL), accounting for approximately 30% of the cases. This group includes primary cutaneous anaplastic large lymphoma (CALCL), lymphomatoid papulosis (LyP) and borderline cases.
These diseases form a spectrum that may show overlapping histopathological, phenotypic and genetic features. The clinical appearance and course are therefore critical for the definite diagnosis. The term “borderline” refers to cases in which, despite careful clinicopathologic correlation, a definite distinction between C-ALCL and LyP cannot be made. However, clinical examination during follow-up will generally disclose whether such patients have C-ALCL or LyP. From a clinical perspective LyP is not considered a malignant disorder, despite demonstration of monoclonality in many cases.
Lymphomatoid papulosis (LyP) is a chronic, recurrent, self-healing skin disease composed of large atypical anaplastic, immunoblastic or Hodgkin-like cells in a marked nflammatory background. Type B mimicking MY; Type C mimicking cALCL; Type D mimicking CD8+ aggressive epidermotropic TCL; Type E mimicking extranodal NK/TCL.
CD30+PCLPDs are the second most common group of the cutaneous T-cell lymphomas (CTCL), accounting for approximately 30% of the cases. This group includes primary cutaneous anaplastic large lymphoma (CALCL), lymphomatoid papulosis (LyP) and borderline cases.
These diseases form a spectrum that may show overlapping histopathological, phenotypic and genetic features. The clinical appearance and course are therefore critical for the definite diagnosis. The term “borderline” refers to cases in which, despite careful clinicopathologic correlation, a definite distinction between C-ALCL and LyP cannot be made. However, clinical examination during follow-up will generally disclose whether such patients have C-ALCL or LyP. From a clinical perspective LyP is not considered a malignant disorder, despite demonstration of monoclonality in many cases.
Lymphomatoid papulosis (LyP) is a chronic, recurrent, self-healing skin disease composed of large atypical anaplastic, immunoblastic or Hodgkin-like cells in a marked nflammatory background. Type B mimicking MY; Type C mimicking cALCL; Type D mimicking CD8+ aggressive epidermotropic TCL; Type E mimicking extranodal NK/TCL.