Cytology shows mixture of small and large lymphocytes (centroblasts).
Diagnosis: Florid follicular hyperplasia (FFH).
Flow cytometry distinction between FFH and follicular lymphoma (FL)
FFH: CD10 dim+, CD20 bright+, surface light chain absent, BCL2-
FL: CD10bright+, CD20 bright+, light chain restriction, BCL2+
Note: some FL may have dim CD10, low or absent surface light chain. Without BCL2 and/or molecular test, flow cytometry study may not able to tell the difference.
Diagnosis: Florid follicular hyperplasia (FFH).
Flow cytometry distinction between FFH and follicular lymphoma (FL)
FFH: CD10 dim+, CD20 bright+, surface light chain absent, BCL2-
FL: CD10bright+, CD20 bright+, light chain restriction, BCL2+
Note: some FL may have dim CD10, low or absent surface light chain. Without BCL2 and/or molecular test, flow cytometry study may not able to tell the difference.