Megakaryocyte in the PBS of iron deficiency anemia.
Megakaryocytes develop from hematopoietic stem cells and reside in the bone marrow (BM). A small portion can leave BM, travel in the blood and relocate to the lungs or other organ systems. However, megakaryocytes are not normally identified in PBSs. The finding of megakaryocytes in the PBS of an adult is usually indicative of a myeloid neoplasm or extramedullary hematopoiesis, and usually also show a leucoerythroblastic reaction. The presence of megakaryocytes in a PBS can also be seen in cases of thrombocytopenia or reactive thrombocytosis due to increased megakaryopoiesis.
Megakaryocytes develop from hematopoietic stem cells and reside in the bone marrow (BM). A small portion can leave BM, travel in the blood and relocate to the lungs or other organ systems. However, megakaryocytes are not normally identified in PBSs. The finding of megakaryocytes in the PBS of an adult is usually indicative of a myeloid neoplasm or extramedullary hematopoiesis, and usually also show a leucoerythroblastic reaction. The presence of megakaryocytes in a PBS can also be seen in cases of thrombocytopenia or reactive thrombocytosis due to increased megakaryopoiesis.